Recent research has used functional magnetic resonance imaging (fMRI) to examine brain regions related to specific subcomponent cognitive processes of verbal working memory, which include initial encoding of material, maintenance of the information over a brief delay interval, and later retrieval of the information. The present study examined each of these subcomponents in 14 healthy adults using a Sternberg verbal working memory task and fMRI. Group analysis revealed several brain regions active during all subcomponent processes, which included dorsolateral and ventrolateral prefrontal, parietal, hippocampal, and premotor cortex. Several other brain regions showed activation limited to specific subcomponent processes.
Bibliographical noteFunding Information:
The authors thank Daryl Bohning, Ph.D., for help with the fMRI scanning task; John Carney, Ph.D., for helpful comments; Berry Anderson and Angela Walker for screening subjects; Carol Hanback and Minnie Dobbins for administrative help; John Walker for bioengineering support; and Deborah Axness for informatics support. This study was funded by a grant to Dr. George from the Defense Advanced Research Projects Agency (DARPA). The CAIR is also supported in part by research grants from the Stanley Foundation, the National Alliance for Research on Schizophrenia and Depression (NARSAD), the Borderline Personality Disorders Research Foundation (BPDRF), and NINDS grant RO1-AG40956.
- Functional magnetic resonance imaging
- Healthy adults
- Sternberg working memory task
- Subcomponent cognitive processes
- Verbal working memory