Functional suppression of long-term sustained response in the human hippocampal formation due to memory distraction

Toshinori Kato, Seiji Ogawa, Kâmil Uǧurbil

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Functional magnetic resonance imaging is used to investigate physiological dynamics in the human hippocampal formation due to memory distraction. A finger-movement task executed following a verbal memory task resulted in decreased verbal memory scores and shortening of active response in the hippocampal formation and the cerebellar dentate nucleus. Verbal rehearsal was excluded as an explanation because this sustained activation was approximately three-fold longer than the duration of the post-task activation observed in classical language processing regions such as Wernicke's and Broca's areas. These interference phenomena provide a physiological basis of memory distraction in the hippocampal formation. (C) 2000 Published by Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume291
Issue number1
DOIs
StatePublished - Sep 8 2000

Bibliographical note

Funding Information:
The authors wish to thank R. Somorjai for use of the EvIdent software package, Peter Erhard, Yoshihiro Takayama, John Strupp for technical support and useful discussion. This work was supported by a grant from National Centers for Research Resources NIH grant RR08079.

Keywords

  • Cerebellum
  • Distraction
  • Functional magnetic resonance imaging
  • Hippocampus
  • Long-term sustained response
  • Memory

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