Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: The hypertension genetic epidemiology network (HyperGEN) study

James S. Pankow; Diane M. Dunn; Steven C. Hunt; Mark F. Leppert; Michael B. Miller; D. C. Rao; Gerardo Heiss; Albert Oberman; Jean Marc Lalouel; Robert B. Weiss

doi:10.1016/j.amjhyper.2004.12.004

Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: The hypertension genetic epidemiology network (HyperGEN) study

James S. Pankow, Diane M. Dunn, Steven C. Hunt, Mark F. Leppert, Michael B. Miller, D. C. Rao, Gerardo Heiss, Albert Oberman, Jean Marc Lalouel, Robert B. Weiss

Epidemiology

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32 Scopus citations

Abstract

Background: Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a postural challenge. Methods: A prior genome scan of postural SBP response in 636 subjects of white ethnicity from 285 hypertensive sibships in the Hypertension Genetic Epidemiology Network (HyperGEN) indicated suggestive evidence for linkage on chromosome 18q21. This study included a de novo set of 452 African American pedigrees from the HyperGEN study and an expanded set of 372 white pedigrees. Variance components linkage analysis of postural SBP change was conducted using microsatellite markers on chromosome 18, and association studies were performed with a common single nucleotide polymorphism (variant 13) in the gene encoding NEDD4L, a key regulator of fine sodium reabsorption in the distal nephron. Results: Combined analysis of all white and African American pedigrees yielded a LOD score of 4.25 at 80 cM on chromosome 18q21, with at least nominal evidence of linkage at this position in both white (LOD: 3.43) and African American (LOD: 1.14) subjects. Postural SBP response was associated with variant 13 of the NEDD4L in a subset of white subjects taking medications effective in treating sodium volume-dependent hypertension (α₁-blockers, calcium channel blockers, and/or diuretics). Conclusion: These data provide further evidence for a quantitative trait locus on chromosome 18q21 influencing postural change in SBP.

Original language	English (US)
Pages (from-to)	672-678
Number of pages	7
Journal	American journal of hypertension
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.amjhyper.2004.12.004
State	Published - May 2005

Bibliographical note

Funding Information:
This hypertension network is funded by the following cooperative agreements (U01) with the National Heart, Lung, and Blood Institute: HL54471, HL54472, HL54473, HL54495, HL54496, HL54497, HL54509, and HL54515.

Keywords

Antihypertensive agents
Blood pressure
Genetics
Polymorphism
Sodium channels

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjhyper.2004.12.004

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Pankow, J. S., Dunn, D. M., Hunt, S. C., Leppert, M. F., Miller, M. B., Rao, D. C., Heiss, G., Oberman, A., Lalouel, J. M., & Weiss, R. B. (2005). Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: The hypertension genetic epidemiology network (HyperGEN) study. American journal of hypertension, 18(5), 672-678. https://doi.org/10.1016/j.amjhyper.2004.12.004

Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: The hypertension genetic epidemiology network (HyperGEN) study. / Pankow, James S.; Dunn, Diane M.; Hunt, Steven C. et al.
In: American journal of hypertension, Vol. 18, No. 5, 05.2005, p. 672-678.

Research output: Contribution to journal › Article › peer-review

Pankow, JS, Dunn, DM, Hunt, SC, Leppert, MF, Miller, MB, Rao, DC, Heiss, G, Oberman, A, Lalouel, JM & Weiss, RB 2005, 'Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: The hypertension genetic epidemiology network (HyperGEN) study', American journal of hypertension, vol. 18, no. 5, pp. 672-678. https://doi.org/10.1016/j.amjhyper.2004.12.004

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abstract = "Background: Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a postural challenge. Methods: A prior genome scan of postural SBP response in 636 subjects of white ethnicity from 285 hypertensive sibships in the Hypertension Genetic Epidemiology Network (HyperGEN) indicated suggestive evidence for linkage on chromosome 18q21. This study included a de novo set of 452 African American pedigrees from the HyperGEN study and an expanded set of 372 white pedigrees. Variance components linkage analysis of postural SBP change was conducted using microsatellite markers on chromosome 18, and association studies were performed with a common single nucleotide polymorphism (variant 13) in the gene encoding NEDD4L, a key regulator of fine sodium reabsorption in the distal nephron. Results: Combined analysis of all white and African American pedigrees yielded a LOD score of 4.25 at 80 cM on chromosome 18q21, with at least nominal evidence of linkage at this position in both white (LOD: 3.43) and African American (LOD: 1.14) subjects. Postural SBP response was associated with variant 13 of the NEDD4L in a subset of white subjects taking medications effective in treating sodium volume-dependent hypertension (α1-blockers, calcium channel blockers, and/or diuretics). Conclusion: These data provide further evidence for a quantitative trait locus on chromosome 18q21 influencing postural change in SBP.",

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note = "Funding Information: This hypertension network is funded by the following cooperative agreements (U01) with the National Heart, Lung, and Blood Institute: HL54471, HL54472, HL54473, HL54495, HL54496, HL54497, HL54509, and HL54515. ",

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AU - Rao, D. C.

AU - Heiss, Gerardo

AU - Oberman, Albert

AU - Lalouel, Jean Marc

AU - Weiss, Robert B.

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N2 - Background: Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a postural challenge. Methods: A prior genome scan of postural SBP response in 636 subjects of white ethnicity from 285 hypertensive sibships in the Hypertension Genetic Epidemiology Network (HyperGEN) indicated suggestive evidence for linkage on chromosome 18q21. This study included a de novo set of 452 African American pedigrees from the HyperGEN study and an expanded set of 372 white pedigrees. Variance components linkage analysis of postural SBP change was conducted using microsatellite markers on chromosome 18, and association studies were performed with a common single nucleotide polymorphism (variant 13) in the gene encoding NEDD4L, a key regulator of fine sodium reabsorption in the distal nephron. Results: Combined analysis of all white and African American pedigrees yielded a LOD score of 4.25 at 80 cM on chromosome 18q21, with at least nominal evidence of linkage at this position in both white (LOD: 3.43) and African American (LOD: 1.14) subjects. Postural SBP response was associated with variant 13 of the NEDD4L in a subset of white subjects taking medications effective in treating sodium volume-dependent hypertension (α1-blockers, calcium channel blockers, and/or diuretics). Conclusion: These data provide further evidence for a quantitative trait locus on chromosome 18q21 influencing postural change in SBP.

AB - Background: Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a postural challenge. Methods: A prior genome scan of postural SBP response in 636 subjects of white ethnicity from 285 hypertensive sibships in the Hypertension Genetic Epidemiology Network (HyperGEN) indicated suggestive evidence for linkage on chromosome 18q21. This study included a de novo set of 452 African American pedigrees from the HyperGEN study and an expanded set of 372 white pedigrees. Variance components linkage analysis of postural SBP change was conducted using microsatellite markers on chromosome 18, and association studies were performed with a common single nucleotide polymorphism (variant 13) in the gene encoding NEDD4L, a key regulator of fine sodium reabsorption in the distal nephron. Results: Combined analysis of all white and African American pedigrees yielded a LOD score of 4.25 at 80 cM on chromosome 18q21, with at least nominal evidence of linkage at this position in both white (LOD: 3.43) and African American (LOD: 1.14) subjects. Postural SBP response was associated with variant 13 of the NEDD4L in a subset of white subjects taking medications effective in treating sodium volume-dependent hypertension (α1-blockers, calcium channel blockers, and/or diuretics). Conclusion: These data provide further evidence for a quantitative trait locus on chromosome 18q21 influencing postural change in SBP.

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Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: The hypertension genetic epidemiology network (HyperGEN) study

Abstract

Bibliographical note

Keywords

UN SDGs

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