G proteins and modulation of insulin secretion

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Abstract

Guanine nucleotide-binding proteins (G proteins) are critically important mediators of many signaltransduction systems. Several important sites regulating stimulus-secretion coupling and release of insulin from pancreatic β-cells are modulated by G proteins. Gs mediates increases in intracellular cAMP associated with hormone-induced stimulation of insulin secretion. Gl mediates decreases in intracellular cAMP caused by inhibitors of insulin secretion, e.g., epinephrine, somatostatin, prostaglandin E2, and galanin. G proteins also regulate ion channels, phospholipases, and distal sites in exocytosis. Cholera and pertussis toxins irreversibly ADP ribosylate G proteins and are important tools that can be used both to manipulate G-protein-dependent modulators of insulin secretion and detect and quantify G proteins by electrophoretic techniques. The stage is set to pursue these initial observations in greater depth and ascertain whether G-protein research will provide important new insights into normal and abnormal regulation of insulin secretion.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalDiabetes
Volume40
Issue number1
DOIs
StatePublished - Jan 1991

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