TY - JOUR
T1 - Gadolinium-ethoxybenzyl–DTPA, a new liver-directed magnetic resonance contrast agent
T2 - Absence of acute hepatotoxic, cardiovascular, or immunogenic effects
AU - Mühler, Andreas
AU - Clément, Olivier
AU - Saeed, Maythem
AU - Lake, John R.
AU - Stites, Daniel P.
AU - Berthezène, Yves
AU - Brasch, Robert C.
PY - 1993/1
Y1 - 1993/1
N2 - Rationale and Objectives: Gadolinium-ethoxybenzyl-DTPA (Gd-EOB–DTPA) is a recently introduced experimental magnetic resonance (MR) contrast agent for hepatic imaging. Although liver enhancement has been investigated in a number of animal models, tolerance evaluations of Gd-EOB–DTPA injection have been limited. Methods: The authors investigated acute hepatotoxicity in an isolated perfused rat liver model, cardiovascular effects in the anesthetized rat, and potential immunogenicity of Gd-EOB–DTPA using detection of specific antibodies. Results: Using perfused rat liver model, no significant deviation could be observed for functional parameters, liver enzymes, or potassium release, comparing Gd-EOB-DTPA to a control, but there was a significant choleresis (+250% bile flow). Hemodynamic effects of Gd-EOB–DTPA were observed after femoral bolus injection, but only with relatively high dosages (0.3—0.5 mmol/kg, 10-fold the likely clinical dose in humans). Experimental conditions, idealized for antibody induction, failed to cause an IgG immune response to Gd-EOB–DTPA in the intact rat. Conclusions: The results further support preliminary conclusions that Gd–EOB–DTPA is a well-tolerated MR contrast agent.
AB - Rationale and Objectives: Gadolinium-ethoxybenzyl-DTPA (Gd-EOB–DTPA) is a recently introduced experimental magnetic resonance (MR) contrast agent for hepatic imaging. Although liver enhancement has been investigated in a number of animal models, tolerance evaluations of Gd-EOB–DTPA injection have been limited. Methods: The authors investigated acute hepatotoxicity in an isolated perfused rat liver model, cardiovascular effects in the anesthetized rat, and potential immunogenicity of Gd-EOB–DTPA using detection of specific antibodies. Results: Using perfused rat liver model, no significant deviation could be observed for functional parameters, liver enzymes, or potassium release, comparing Gd-EOB-DTPA to a control, but there was a significant choleresis (+250% bile flow). Hemodynamic effects of Gd-EOB–DTPA were observed after femoral bolus injection, but only with relatively high dosages (0.3—0.5 mmol/kg, 10-fold the likely clinical dose in humans). Experimental conditions, idealized for antibody induction, failed to cause an IgG immune response to Gd-EOB–DTPA in the intact rat. Conclusions: The results further support preliminary conclusions that Gd–EOB–DTPA is a well-tolerated MR contrast agent.
KW - Coronary angiography
KW - Isotonic iodixanol
KW - Left ventricular function
KW - Sodium-calcium balance
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U2 - 10.1097/00004424-199301000-00008
DO - 10.1097/00004424-199301000-00008
M3 - Article
C2 - 8425849
AN - SCOPUS:0027399451
SN - 0020-9996
VL - 28
SP - 26
EP - 32
JO - Investigative Radiology
JF - Investigative Radiology
IS - 1
ER -