Gadolinium-ethoxybenzyl–DTPA, a new liver-directed magnetic resonance contrast agent: Absence of acute hepatotoxic, cardiovascular, or immunogenic effects

Andreas Mühler, Olivier Clément, Maythem Saeed, John R. Lake, Daniel P. Stites, Yves Berthezène, Robert C. Brasch

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Rationale and Objectives: Gadolinium-ethoxybenzyl-DTPA (Gd-EOB–DTPA) is a recently introduced experimental magnetic resonance (MR) contrast agent for hepatic imaging. Although liver enhancement has been investigated in a number of animal models, tolerance evaluations of Gd-EOB–DTPA injection have been limited. Methods: The authors investigated acute hepatotoxicity in an isolated perfused rat liver model, cardiovascular effects in the anesthetized rat, and potential immunogenicity of Gd-EOB–DTPA using detection of specific antibodies. Results: Using perfused rat liver model, no significant deviation could be observed for functional parameters, liver enzymes, or potassium release, comparing Gd-EOB-DTPA to a control, but there was a significant choleresis (+250% bile flow). Hemodynamic effects of Gd-EOB–DTPA were observed after femoral bolus injection, but only with relatively high dosages (0.3—0.5 mmol/kg, 10-fold the likely clinical dose in humans). Experimental conditions, idealized for antibody induction, failed to cause an IgG immune response to Gd-EOB–DTPA in the intact rat. Conclusions: The results further support preliminary conclusions that Gd–EOB–DTPA is a well-tolerated MR contrast agent.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalInvestigative Radiology
Volume28
Issue number1
DOIs
StatePublished - Jan 1993

Keywords

  • Coronary angiography
  • Isotonic iodixanol
  • Left ventricular function
  • Sodium-calcium balance

Fingerprint

Dive into the research topics of 'Gadolinium-ethoxybenzyl–DTPA, a new liver-directed magnetic resonance contrast agent: Absence of acute hepatotoxic, cardiovascular, or immunogenic effects'. Together they form a unique fingerprint.

Cite this