GALACTOSE CONSUMPTION AND METABOLISM IN RELATION TO THE RISK OF OVARIAN CANCER

Daniel W. Cramer, Walter C. Willett, Debra A. Bell, Won G. Ng, Bernard L. Harlow, William R. Welch, Robert E. Scully, Robert C. Knapp

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133 Scopus citations

Abstract

In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined. Yogurt was consumed at least monthly by 49% of cases and 36% of controls. The mean transferase activity of cases was significantly lower than that of controls. When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1·17 compared with 0·98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio. Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalThe Lancet
Volume334
Issue number8654
DOIs
StatePublished - Jul 8 1989

Bibliographical note

Funding Information:
Ms Leslie Fortier, Ms Dawn Harvey, Ms Judy Geller, and Ms Emily Lublin is gratefully acknowledged. This study was supported by grant R01 CA 42008 from the National Cancer Institute.

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