Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Victor L.J.L. Thijssen; Ruben Postel; Ricardo J.M.G.E. Brandwijk; Ruud P.M. Dings; Irina Nesmelova; Sietske Satijn; Nicole Verhofstad; Yusaku Nakabeppu; Linda G. Baum; Jeroen Bakkers; Kevin H. Mayo; Françoise Poirier; Arjan W. Griffioen

doi:10.1073/pnas.0603883103

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Victor L.J.L. Thijssen, Ruben Postel, Ricardo J.M.G.E. Brandwijk, Ruud P.M. Dings, Irina Nesmelova, Sietske Satijn, Nicole Verhofstad, Yusaku Nakabeppu, Linda G. Baum, Jeroen Bakkers, Kevin H. Mayo, Françoise Poirier, Arjan W. Griffioen

Chemical and Structural Biology (TMED)

Research output: Contribution to journal › Article › peer-review

410 Scopus citations

Abstract

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

Original language	English (US)
Pages (from-to)	15975-15980
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	103
Issue number	43
DOIs	https://doi.org/10.1073/pnas.0603883103
State	Published - Oct 24 2006

Keywords

Anginex
Angiostatic therapy
Endothelial cell
Galectin
Tumor models

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Thijssen, V. L. J. L., Postel, R., Brandwijk, R. J. M. G. E., Dings, R. P. M., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L. G., Bakkers, J., Mayo, K. H., Poirier, F., & Griffioen, A. W. (2006). Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proceedings of the National Academy of Sciences of the United States of America, 103(43), 15975-15980. https://doi.org/10.1073/pnas.0603883103

Thijssen, VLJL, Postel, R, Brandwijk, RJMGE, Dings, RPM, Nesmelova, I, Satijn, S, Verhofstad, N, Nakabeppu, Y, Baum, LG, Bakkers, J, Mayo, KH, Poirier, F & Griffioen, AW 2006, 'Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 43, pp. 15975-15980. https://doi.org/10.1073/pnas.0603883103

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abstract = "We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.",

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AU - Nesmelova, Irina

AU - Satijn, Sietske

AU - Verhofstad, Nicole

AU - Nakabeppu, Yusaku

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AU - Mayo, Kevin H.

AU - Poirier, Françoise

AU - Griffioen, Arjan W.

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KW - Anginex

KW - Angiostatic therapy

KW - Endothelial cell

KW - Galectin

KW - Tumor models

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Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Abstract

Keywords

UN SDGs

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