Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.
|Original language||English (US)|
|Journal||Annals of Translational Medicine|
|State||Published - Sep 2014|
- Galectin-3 (Gal-3)
- Multiple myeloma (MM)