Abstract
Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.
Original language | English (US) |
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Article number | 87 |
Journal | Annals of Translational Medicine |
Volume | 2 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2014 |
Bibliographical note
Publisher Copyright:© Annals of Translational Medicine. All rights reserved.
Keywords
- Galectin-3 (Gal-3)
- Galectins
- Leukemia
- Lymphomas
- Multiple myeloma (MM)