Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient

J. E. Julin; J. H. Van Burik; W. Krivit; C. Webb; C. J. Holman; H. B. Clark; Henry H. Balfour

doi:10.1034/j.1399-3062.2002.02005.x

Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient

J. E. Julin, J. H. Van Burik, W. Krivit, C. Webb, C. J. Holman, H. B. Clark, Henry H. Balfour

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Abstract

A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found.

Original language	English (US)
Pages (from-to)	201-206
Number of pages	6
Journal	Transplant Infectious Disease
Volume	4
Issue number	4
DOIs	https://doi.org/10.1034/j.1399-3062.2002.02005.x
State	Published - Dec 2002

Keywords

Cytomegalovirus
Encephalitis
Ganciclovir resistance
Metachromatic leukodystrophy
Transplantation
UL97 mutation

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title = "Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient",

abstract = "A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found.",

keywords = "Cytomegalovirus, Encephalitis, Ganciclovir resistance, Metachromatic leukodystrophy, Transplantation, UL97 mutation",

author = "Julin, {J. E.} and {Van Burik}, {J. H.} and W. Krivit and C. Webb and Holman, {C. J.} and Clark, {H. B.} and Balfour, {Henry H.}",

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AU - Julin, J. E.

AU - Van Burik, J. H.

AU - Krivit, W.

AU - Webb, C.

AU - Holman, C. J.

AU - Clark, H. B.

AU - Balfour, Henry H.

PY - 2002/12

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KW - Cytomegalovirus

KW - Encephalitis

KW - Ganciclovir resistance

KW - Metachromatic leukodystrophy

KW - Transplantation

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Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient

Abstract

Keywords

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