Antigastric mucosal antibody reduces iron absorption in normal and anemic rats. This appears to result from the formation of large antibody-antigen complexes with the iron which are not easily absorbed. Such a mechanism might account for the idiopathic hypochromic microcytic anemia associated with complete achlorhydria and circulating parietal antibody. In this situation lack of acid might prevent degradation of the large molecules to a more easily absorbed form. A simple technique for studying iron binding in vitro was devised.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jun 1969|
Bibliographical noteFunding Information:
Supported by the John Hartford Foundation and by the National Institute of Arthritis and Metabolic Diseases Research Grant No. AM 10976-01.