Gastrin cell populations after highly selective vagotomy in the dog

Daniel H. Dunn; Cezar Decanini; Margaret E. Bonsack; M. Michael Eisenberg; John P. Delaney

doi:10.1016/0002-9610(79)90020-5

Gastrin cell populations after highly selective vagotomy in the dog

Daniel H. Dunn, Cezar Decanini, Margaret E. Bonsack, M. Michael Eisenberg, John P. Delaney

Surgery

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Highly selective vagotomy was performed on five dogs. Postoperatively, gastrin cell (G cell) hyperplasia occurred in all dogs. Mean preoperative G cell numbers increased from 350 to 530/cm mucosal length (p < 0.02). Antral tissue gastrin also increased by 100 per cent (6.7 × 10⁶ to 13.7 × 10⁶ pg/gm tissue, p < 0.05). Basal and stimulated serum gastrin were unchanged following highly selective vagotomy. The cause for G cell hyperplasia is not clear, but is probably multifactorial.

Original language	English (US)
Pages (from-to)	111-115
Number of pages	5
Journal	The American Journal of Surgery
Volume	137
Issue number	1
DOIs	https://doi.org/10.1016/0002-9610(79)90020-5
State	Published - Jan 1979

Bibliographical note

Funding Information:
From the Department of Surgery, University of Minnesota Health Sciences Center, Minneapolis, Minnesota. This work was supported by USPHS grant #5ROi AM19326-02. National Institutes of Health. Reprint requests should be addressed to John P. Delaney, MO, PRD. Department of Surgery, University Hospitals, Box 89, 420 Delaware Street SE, Minneapolis, Minnesota 55455. Presented at the Nineteenth Annual Meeting of the Society for Surgery of the Alimentary Tract, Las Vegas, Nevada, May 23-24. 1978.

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abstract = "Highly selective vagotomy was performed on five dogs. Postoperatively, gastrin cell (G cell) hyperplasia occurred in all dogs. Mean preoperative G cell numbers increased from 350 to 530/cm mucosal length (p < 0.02). Antral tissue gastrin also increased by 100 per cent (6.7 × 106 to 13.7 × 106 pg/gm tissue, p < 0.05). Basal and stimulated serum gastrin were unchanged following highly selective vagotomy. The cause for G cell hyperplasia is not clear, but is probably multifactorial.",

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Gastrin cell populations after highly selective vagotomy in the dog

Abstract

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