Gastrin cell populations after highly selective vagotomy in the dog

Daniel H. Dunn, Cezar Decanini, Margaret E. Bonsack, M. Michael Eisenberg, John P. Delaney

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Highly selective vagotomy was performed on five dogs. Postoperatively, gastrin cell (G cell) hyperplasia occurred in all dogs. Mean preoperative G cell numbers increased from 350 to 530/cm mucosal length (p < 0.02). Antral tissue gastrin also increased by 100 per cent (6.7 × 106 to 13.7 × 106 pg/gm tissue, p < 0.05). Basal and stimulated serum gastrin were unchanged following highly selective vagotomy. The cause for G cell hyperplasia is not clear, but is probably multifactorial.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalThe American Journal of Surgery
Issue number1
StatePublished - Jan 1979

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