Abstract
Gastrointestinal perforations frequently represent a lethal complication of immunosuppression. Of 325 renal transplant recipients treated with cyclosporin (CsA), 4 patients (1.2%) developed gastrointestinal perforation: 1 from gastric ulcer and 3 from colonic diverticula. All patients underwent operative treatment and all survived without complications. Three patients maintained a well-functioning allograft. In comparison to azathioprine, CsA does not seem to greatly affect the immune response to bacterial infections, thus representing a considerable advantage in the management of serious gastrointestinal complications.
Original language | English (US) |
---|---|
Pages (from-to) | 137-141 |
Number of pages | 5 |
Journal | World Journal of Surgery |
Volume | 10 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1986 |