The true prevalence of gastroparesis in the general population is not clear. Vague symptoms of nausea and abdominal distension correlate poorly with gastric emptying. The proximal part of the stomach (body and fundus) is mainly concerned with storage function, while the antrum functions as a grinder. The interstitial cells of Cajal, the pacemaker cells coordinate the fed pattern that leads to gastric emptying. The functions are well preserved in healthy aging. Etiological factors for delayed gastric emptying include effects of diseases and drugs; common causes include diabetes mellitus, Parkinson's disease, hypothyroidism, chronic renal failure, and gastric cancer. Clinical presentation is nonspecific, with nausea, vomiting, and bloating. Diagnosis involves history, examination, endoscopy, and scintigraphy. Management is unsatisfactory, but includes lifestyle modification, pharmacotherapy, and gastric electrical stimulation.