Abstract
The purpose of this study was to clarify the significance of recipient gender status on lung transplant outcomes in a large single-institution experience spanning three decades, we analyzed data from all lung transplants performed in our institution since 1986. Kaplan-Meier curves and Cox proportional hazard models were used to evaluate the effect of recipient characteristics on survival and BOS score ≥1-free survival. Logistic regression analysis was used to explore the association of gender with short-term graft function. About 876 lung transplants were performed between 1986 and 2016. Kaplan-Meier survival estimates at 5 years post-transplant for females vs males in the LAS era were 71% vs 58%. In the LAS era, females showed greater unadjusted BOS≥1-free survival than males (35% vs 25%, P=.02) over 5 years. Female gender was the only factor in the LAS era significantly associated with improved adjusted 5-year survival [HR 0.56 (95% CI 0.33, 0.95) P=.03]. Conversely, in the pre-LAS era female gender was not associated with improved survival. Female recipients showed significantly improved survival over 5 years compared to males in the LAS era. A prospective analysis of biologic and immunologic differences is warranted.
Original language | English (US) |
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Article number | e12889 |
Journal | Clinical Transplantation |
Volume | 31 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2017 |
Bibliographical note
Publisher Copyright:© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Keywords
- bronchiolitis obliterans syndrome
- clinical outcomes
- gender
- lung transplant
- primary graft dysfunction
- recipient factors