Gene expression profiling in murine obliterative airway disease

Jeffrey D. Lande, Stacy L. Dalheimer, Daniel L Mueller, Marshall I Hertz, Richard A. King

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Lung and heart-lung transplantation are effective treatments for many diseases unresponsive to other therapy. However, long-term survival of recipients is limited by the development of obliterative bronchiolitis (OB). In this study, microarray analysis of a heterotopic mouse model of obliterative airway disease (OAD) was used to test the hypothesis that the expression and patterns of genes will correlate with specific changes in tracheal tissue developing a response to allotransplantation and the infiltrating cells manifesting these changes. Expression profiles observed were in accordance with the current paradigm of a predictable sequence of events, beginning with airway injury; an innate immune response followed by an adaptive immune response, including both cell-mediated and humoral components; and eventual loss of airway epithelial cells. These observations confirm and expand the list of genes and molecular processes that can be studied as potential surrogate markers or targets for intervention of OB.

Original languageEnglish (US)
Pages (from-to)2170-2184
Number of pages15
JournalAmerican Journal of Transplantation
Volume5
Issue number9
DOIs
StatePublished - Sep 2005

Keywords

  • Gene expression
  • Lung transplantation
  • Obliterative bronchiolitis
  • Rejection

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