TY - JOUR
T1 - Gene marking and gene therapy for transplantation medicine
AU - Dilloo, Dagmar
AU - Rill, Donna R.
AU - Grossmann, Michael E.
AU - Leimig, Thasia
AU - Brenner, Malcolm K.
PY - 1996/10
Y1 - 1996/10
N2 - The classic application for gene therapy is in the the correction of single gene defects, although this has been complicated by the low efficiency of gene transfer into hematopoietic cells. Gene therapy, however, has potential for the modulation of tumor cell growth, drug sensitivity, and antitumor immune responses. In addition, gene marking can be used, in spite of this limited transfer efficiency, to provide information on hematopoiesis, sources of cancer relapse after stem cell transplant, and the relative efficacy of graft manipulation techniques. This article reviews the applications of gene therapy and gene marking in transplantation medicine.
AB - The classic application for gene therapy is in the the correction of single gene defects, although this has been complicated by the low efficiency of gene transfer into hematopoietic cells. Gene therapy, however, has potential for the modulation of tumor cell growth, drug sensitivity, and antitumor immune responses. In addition, gene marking can be used, in spite of this limited transfer efficiency, to provide information on hematopoiesis, sources of cancer relapse after stem cell transplant, and the relative efficacy of graft manipulation techniques. This article reviews the applications of gene therapy and gene marking in transplantation medicine.
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U2 - 10.1089/scd.1.1996.5.553
DO - 10.1089/scd.1.1996.5.553
M3 - Article
C2 - 8938528
AN - SCOPUS:0029903992
SN - 1525-8165
VL - 5
SP - 553
EP - 555
JO - Journal of Hematotherapy and Stem Cell Research
JF - Journal of Hematotherapy and Stem Cell Research
IS - 5
ER -
