TY - JOUR
T1 - General anesthetic effects on compound muscle action potentials elicited by single or dual spinal cord stimulation
AU - Yamada, Hiroshi
AU - Transfeldt, Ensor E.
AU - Tamaki, Utetsuya
AU - Nishiura, Hhiroaki
AU - Taylor, Benjamin A.
AU - Torres, Fernando
AU - Iaizzo, Paul A.
PY - 1995/4
Y1 - 1995/4
N2 - The aim of this study was to determine the optimal conditions, during general anesthesia, to obtain reproducible monitoring of compound muscle action potentials (CM APs) as a means to evaluate motor tract integrity. The CM APs were recorded in the soleus muscle of cats and were elicited by either single or double pulse stimulations (with various amplitudes and interpulse durations) of the spinal cord via an epidural electrode. The effects of various depths of general anesthesia with halothane, enflurane, isoflurane, or propofol on such recordings were also determined. For each agent, the CMAP amplitudes were significantly greater following double pulse stimulations (2-ms optimal interpulse duration) relative to single pulses. The CMAP amplitudes elicited by double pulse stimulations were the same at propofol concentrations of 50, 100, 150, and 200 jug/kg/ min, whereas those for each volatile anesthetic, at all concentrations studied (0.5%, 1.0%, 1.5%, or 2.0%), were significantly lower. It was concluded that to obtain reliable CMAP amplitudes, general anesthesia with propofol should be employed and the potentials should be evoked by double pulse stimulations.
AB - The aim of this study was to determine the optimal conditions, during general anesthesia, to obtain reproducible monitoring of compound muscle action potentials (CM APs) as a means to evaluate motor tract integrity. The CM APs were recorded in the soleus muscle of cats and were elicited by either single or double pulse stimulations (with various amplitudes and interpulse durations) of the spinal cord via an epidural electrode. The effects of various depths of general anesthesia with halothane, enflurane, isoflurane, or propofol on such recordings were also determined. For each agent, the CMAP amplitudes were significantly greater following double pulse stimulations (2-ms optimal interpulse duration) relative to single pulses. The CMAP amplitudes elicited by double pulse stimulations were the same at propofol concentrations of 50, 100, 150, and 200 jug/kg/ min, whereas those for each volatile anesthetic, at all concentrations studied (0.5%, 1.0%, 1.5%, or 2.0%), were significantly lower. It was concluded that to obtain reliable CMAP amplitudes, general anesthesia with propofol should be employed and the potentials should be evoked by double pulse stimulations.
KW - Anesthetics
KW - CMAPs
KW - Dual stimulation
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U2 - 10.1097/00002517-199504000-00011
DO - 10.1097/00002517-199504000-00011
M3 - Article
C2 - 7606124
AN - SCOPUS:0028954601
SN - 0895-0385
VL - 8
SP - 157
EP - 162
JO - Journal of Spinal Disorders
JF - Journal of Spinal Disorders
IS - 2
ER -