Generation and characterization of KsprtTA and KsptTA transgenic mice

Xinchao Pan, Erin V. Small, Peter Igarashi, Thomas J. Carroll

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The advent of technologies that allow tissue specific expression or ablation of genes has contributed enormously to our knowledge of the mechanism regulating organ development and maintenance in mice. The tetracycline inducible system allows reversible regulation of gene products upon administration of doxycycline. Here we describe the generation and activity of two transgenic lines expressing the cDNAs for the Tet responsive transcription factors rtTA and tTA (Tet-on and off) respectively under the control of an element that drives expression in the epithelium of the developing and adult kidney. Both lines show inducible and reversible activity in the embryonic and adult organ.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalGenesis
Volume51
Issue number6
DOIs
StatePublished - Jun 1 2013

Keywords

  • Kidney development
  • Kidney epithelium
  • Kidney tubule
  • Tet-off
  • Tet-on

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