Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis

Angela Panoskaltsis-Mortari, R. Maarten Egeler, Thomas M. Yaeger, Sumiko Yoneji, Laura Schmitz, Frank Lilly, Mark E. Nesbit, Bruce R. Blazar

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Malignant histiocytosis sarcoma virus (MHSV) arose as a recombinant of c-Harvey-ras murine sarcoma virus (Ha-MuSV) and Friend mink cell focus- forming virus (F-MCFV). It is a defective acute transforming retrovirus that, along with Friend murine leukemia helper virus (F-MuLV), induces malignant histiocytosis (MH) in susceptible adult mice. We have assessed the in vivo susceptibility to MHSV in inbred homozygous, F1 hybrid, congenic, and recombinant inbred (RI) mice. We have shown that: (1) in vivo resistance to MHSV is multigenic, regulated by MHC and non-MHC genes in a different fashion than with F-MCFV, F-MuLV, or Ha-MuSV; (2) using BXD RI mice, the resistance phenotype is linked with 95.8% probability to two linked loci, Pmv-9 and Iapls3-14, on chromosome 13 (homologous to the area of human chromosome 5 for which a chromosomal break point at position 5q35 is associated with human MH); and (3) CD4+ T cells are critical for MHSV resistance.

Original languageEnglish (US)
Pages (from-to)441-450
Number of pages10
JournalJournal of Leukocyte Biology
Volume64
Issue number4
DOIs
StatePublished - Oct 1998

Keywords

  • CD4 T cells
  • Genetic mapping
  • MHC
  • Macrophage
  • ras

Fingerprint Dive into the research topics of 'Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis'. Together they form a unique fingerprint.

Cite this