Genetic characterization of orf viruses isolated from various ruminant species of a zoo

J. Guo, J. Rasmussen, A. Wünschmann, A. De La Concha-Bermejillo

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Abstract

In the present study, an outbreak of proliferative dermatitis in musk ox (Ovibos moschatus), Sichuan takin (Budorcas taxicolor tibetana) and domestic Shetland sheep (Ovis aries) in a zoo is described. Skin lesions consisted of severe, persistent, multifocal, proliferative dermatitis in musk ox, and mild, transient, focal, dermatitis in the Sichuan takin and Shetland sheep. Parapoxviruses were isolated from skin lesions, and characterized by restriction enzyme analysis and partial gene sequencing. The results of this investigation indicate that the outbreak of proliferative dermatitis was due to infection by a single parapoxvirus, which is genetically closely related to other orf virus (ORFV) strains but distant to bovine papular stomatitis virus (BPSV) and pseudocowpox virus (PCPV).

Original languageEnglish (US)
Pages (from-to)81-92
Number of pages12
JournalVeterinary Microbiology
Volume99
Issue number2
DOIs
StatePublished - Apr 5 2004

Bibliographical note

Funding Information:
This research was funded by grants from the Texas Agricultural Experiment Station, the Texas Food and Fibers Commission, the United States Agency for International Development (USAID) through the Association Liaison Office (ALO) for University Cooperation in Development, and from proceeds from the sale of orf virus vaccine.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Bovine papular stomatitis virus (BPSV)
  • Musk ox
  • Orf virus (ORFV)
  • Parapoxvirus
  • Pseudocowpox virus (PCPV)
  • Shetland sheep
  • Sichuan takin

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