Genetic diversity of the African malaria vector anopheles gambiae

Alistair Miles; Nicholas J. Harding; Giordano Bottà; Chris S. Clarkson; Tiago Antão; Krzysztof Kozak; Daniel R. Schrider; Andrew D. Kern; Seth Redmond; Igor Sharakhov; Richard D. Pearson; Christina Bergey; Michael C. Fontaine; Martin J. Donnelly; Mara K.N. Lawniczak; Diego Ayala; Nora J. Besansky; Austin Burt; Beniamino Caputo; Alessandra Della Torre; H. Charles J. Godfray; Matthew W. Hahn; Janet Midega; Daniel E. Neafsey; Samantha O'Loughlin; João Pinto; Michelle M. Riehle; Kenneth D. Vernick; David Weetman; Craig S. Wilding; Bradley J. White; Arlete D. Troco; Abdoulaye Diabaté; Carlo Costantini; Kyanne R. Rohatgi; Nohal Elissa; Boubacar Coulibaly; João Dinis; Charles Mbogo; Philip Bejon; Henry D. Mawejje; Jim Stalker; Kirk Rockett; Eleanor Drury; Daniel Mead; Anna Jeffreys; Christina Hubbart; Kate Rowlands; Alison T. Isaacs; Dushyanth Jyothi; Cinzia Malangone; Paul Vauterin; Ben Jeffery; Ian Wright; Lee Hart; Krzysztof Kluczyński; Victoria Cornelius; Bronwyn Macinnis; Christa Henrichs; Rachel Giacomantonio; Dominic P. Kwiatkowski

doi:10.1038/nature24995

Genetic diversity of the African malaria vector anopheles gambiae

Alistair Miles, Nicholas J. Harding, Giordano Bottà, Chris S. Clarkson, Tiago Antão, Krzysztof Kozak, Daniel R. Schrider, Andrew D. Kern, Seth Redmond, Igor Sharakhov, Richard D. Pearson, Christina Bergey, Michael C. Fontaine, Martin J. Donnelly, Mara K.N. Lawniczak, Diego Ayala, Nora J. Besansky, Austin Burt, Beniamino Caputo, Alessandra Della TorreH. Charles J. Godfray, Matthew W. Hahn, Janet Midega, Daniel E. Neafsey, Samantha O'Loughlin, João Pinto, Michelle M. Riehle, Kenneth D. Vernick, David Weetman, Craig S. Wilding, Bradley J. White, Arlete D. Troco, Abdoulaye Diabaté, Carlo Costantini, Kyanne R. Rohatgi, Nohal Elissa, Boubacar Coulibaly, João Dinis, Charles Mbogo, Philip Bejon, Henry D. Mawejje, Jim Stalker, Kirk Rockett, Eleanor Drury, Daniel Mead, Anna Jeffreys, Christina Hubbart, Kate Rowlands, Alison T. Isaacs, Dushyanth Jyothi, Cinzia Malangone, Paul Vauterin, Ben Jeffery, Ian Wright, Lee Hart, Krzysztof Kluczyński, Victoria Cornelius, Bronwyn Macinnis, Christa Henrichs, Rachel Giacomantonio, Dominic P. Kwiatkowski

Microbiology

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Abstract

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

Original language	English (US)
Pages (from-to)	96-100
Number of pages	5
Journal	Nature
Volume	552
DOIs	https://doi.org/10.1038/nature24995
State	Published - Dec 7 2017

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© 2017 Macmillan Publishers Limited, Part of Springer Nature. All Rights Reserved.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026373

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Miles, A., Harding, N. J., Bottà, G., Clarkson, C. S., Antão, T., Kozak, K., Schrider, D. R., Kern, A. D., Redmond, S., Sharakhov, I., Pearson, R. D., Bergey, C., Fontaine, M. C., Donnelly, M. J., Lawniczak, M. K. N., Ayala, D., Besansky, N. J., Burt, A., Caputo, B., ... Kwiatkowski, D. P. (2017). Genetic diversity of the African malaria vector anopheles gambiae. Nature, 552, 96-100. https://doi.org/10.1038/nature24995

Miles, A, Harding, NJ, Bottà, G, Clarkson, CS, Antão, T, Kozak, K, Schrider, DR, Kern, AD, Redmond, S, Sharakhov, I, Pearson, RD, Bergey, C, Fontaine, MC, Donnelly, MJ, Lawniczak, MKN, Ayala, D, Besansky, NJ, Burt, A, Caputo, B, Torre, AD, Godfray, HCJ, Hahn, MW, Midega, J, Neafsey, DE, O'Loughlin, S, Pinto, J, Riehle, MM, Vernick, KD, Weetman, D, Wilding, CS, White, BJ, Troco, AD, Diabaté, A, Costantini, C, Rohatgi, KR, Elissa, N, Coulibaly, B, Dinis, J, Mbogo, C, Bejon, P, Mawejje, HD, Stalker, J, Rockett, K, Drury, E, Mead, D, Jeffreys, A, Hubbart, C, Rowlands, K, Isaacs, AT, Jyothi, D, Malangone, C, Vauterin, P, Jeffery, B, Wright, I, Hart, L, Kluczyński, K, Cornelius, V, Macinnis, B, Henrichs, C, Giacomantonio, R & Kwiatkowski, DP 2017, 'Genetic diversity of the African malaria vector anopheles gambiae', Nature, vol. 552, pp. 96-100. https://doi.org/10.1038/nature24995

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abstract = "The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.",

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AU - Hahn, Matthew W.

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AU - Vernick, Kenneth D.

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AU - Kluczyński, Krzysztof

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Genetic diversity of the African malaria vector anopheles gambiae

Abstract

Bibliographical note

UN SDGs

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