Genetic Factors and Susceptibility to Diabetic Nephropathy

Jonathan P. Tolins; Leopoldo Raij; Michael Mauer; Michael W. Steffes; David M. Brown; Andrzej S. Krolewski; Mitzy Canessa; James H. Warram; Lori M.b. Laffel; A. Richard Christlieb; William C. Knowler; Lawrence I. Rand; Giancarlo Viberti

doi:10.1056/NEJM198807213190316

Genetic Factors and Susceptibility to Diabetic Nephropathy

Jonathan P. Tolins, Leopoldo Raij, Michael Mauer, Michael W. Steffes, David M. Brown, Andrzej S. Krolewski, Mitzy Canessa, James H. Warram, Lori M.b. Laffel, A. Richard Christlieb, William C. Knowler, Lawrence I. Rand, Giancarlo Viberti

Pediatrics - Nephrology

Research output: Contribution to journal › Letter › peer-review

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Abstract

To the Editor: Krolewski et al.¹ and Mangili et al.² (Jan. 21 issue) propose that the cohort of patients with insulin-dependent diabetes mellitus in whom diabetic nephropathy is destined to develop may be composed of patients with a genetic predisposition to essential hypertension. Although the mechanism of this association may be difficult to determine in patients, some insight can be gained from the examination of data obtained from experimental models. In experimental diabetes in rats, renal vasodilatation, predominantly of the preglomerular resistance vessels, allows the transmission of systemic arterial pressure freely to the glomerular capillary, with subsequent hyperfiltration, hyperperfusion, and.

Original language	English (US)
Pages (from-to)	180-182
Number of pages	3
Journal	New England Journal of Medicine
Volume	319
Issue number	3
DOIs	https://doi.org/10.1056/NEJM198807213190316
State	Published - Jul 21 1988

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title = "Genetic Factors and Susceptibility to Diabetic Nephropathy",

abstract = "To the Editor: Krolewski et al.1 and Mangili et al.2 (Jan. 21 issue) propose that the cohort of patients with insulin-dependent diabetes mellitus in whom diabetic nephropathy is destined to develop may be composed of patients with a genetic predisposition to essential hypertension. Although the mechanism of this association may be difficult to determine in patients, some insight can be gained from the examination of data obtained from experimental models. In experimental diabetes in rats, renal vasodilatation, predominantly of the preglomerular resistance vessels, allows the transmission of systemic arterial pressure freely to the glomerular capillary, with subsequent hyperfiltration, hyperperfusion, and.",

author = "Tolins, {Jonathan P.} and Leopoldo Raij and Michael Mauer and Steffes, {Michael W.} and Brown, {David M.} and Krolewski, {Andrzej S.} and Mitzy Canessa and Warram, {James H.} and Laffel, {Lori M.b.} and Christlieb, {A. Richard} and Knowler, {William C.} and Rand, {Lawrence I.} and Giancarlo Viberti",

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T1 - Genetic Factors and Susceptibility to Diabetic Nephropathy

AU - Tolins, Jonathan P.

AU - Raij, Leopoldo

AU - Mauer, Michael

AU - Steffes, Michael W.

AU - Brown, David M.

AU - Krolewski, Andrzej S.

AU - Canessa, Mitzy

AU - Warram, James H.

AU - Laffel, Lori M.b.

AU - Christlieb, A. Richard

AU - Knowler, William C.

AU - Rand, Lawrence I.

AU - Viberti, Giancarlo

PY - 1988/7/21

Y1 - 1988/7/21

N2 - To the Editor: Krolewski et al.1 and Mangili et al.2 (Jan. 21 issue) propose that the cohort of patients with insulin-dependent diabetes mellitus in whom diabetic nephropathy is destined to develop may be composed of patients with a genetic predisposition to essential hypertension. Although the mechanism of this association may be difficult to determine in patients, some insight can be gained from the examination of data obtained from experimental models. In experimental diabetes in rats, renal vasodilatation, predominantly of the preglomerular resistance vessels, allows the transmission of systemic arterial pressure freely to the glomerular capillary, with subsequent hyperfiltration, hyperperfusion, and.

AB - To the Editor: Krolewski et al.1 and Mangili et al.2 (Jan. 21 issue) propose that the cohort of patients with insulin-dependent diabetes mellitus in whom diabetic nephropathy is destined to develop may be composed of patients with a genetic predisposition to essential hypertension. Although the mechanism of this association may be difficult to determine in patients, some insight can be gained from the examination of data obtained from experimental models. In experimental diabetes in rats, renal vasodilatation, predominantly of the preglomerular resistance vessels, allows the transmission of systemic arterial pressure freely to the glomerular capillary, with subsequent hyperfiltration, hyperperfusion, and.

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

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ER -

Genetic Factors and Susceptibility to Diabetic Nephropathy

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