Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21

S. A. Smith; D. F. Easton; D. Ford; J. Peto; K. Anderson; D. Averill; M. Stratton; M. Ponder; C. Pye; B. A J Ponder

Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21

S. A. Smith, D. F. Easton, D. Ford, J. Peto, K. Anderson, D. Averill, M. Stratton, M. Ponder, C. Pye, B. A J Ponder

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Abstract

In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at θ = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.

Original language	English (US)
Pages (from-to)	767-776
Number of pages	10
Journal	American Journal of Human Genetics
Volume	52
Issue number	4
State	Published - Apr 1993

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abstract = "In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at θ = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.",

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AU - Ford, D.

AU - Peto, J.

AU - Anderson, K.

AU - Averill, D.

AU - Stratton, M.

AU - Ponder, M.

AU - Pye, C.

AU - Ponder, B. A J

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AB - In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at θ = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.

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Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21

Abstract

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