Abstract
We studied a family with nonprogressive congenital ataxia (NPCA) previously reported in 1985. Follow-up evaluation documented a nonprogressive course. Older family members developed ataxic spells and vertical oscillopsia triggered by stress and exercise. Linkage analysis using a 10K single-nucleotide polymorphism array found suggestive linkage to four loci on chromosomes 1q44, 5q35.1-35.3, 7q36.2-36.3, and 9q31.2-32 and ruled out linkage to the NPCA locus on 3p, proving genetic heterogeneity for autosomal dominant NPCA.
Original language | English (US) |
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Pages (from-to) | 1704-1706 |
Number of pages | 3 |
Journal | Neurology |
Volume | 67 |
Issue number | 9 |
DOIs | |
State | Published - Nov 2006 |
Externally published | Yes |