Genetic influences on brain gene expression in rats selected for tameness and aggression

Henrike O. Heyne, Susann Lautenschläger, Ronald Nelson, François Besnier,  maxime Rotival, Alexander Cagan, Rimma Kozhemyakina, Irina Z. Plyusnina, Lyudmila Trut, Örjan Carlborg, Enrico Petretto, Leonid Kruglyak, Svante Pääbo, Torsten Schöneberg, Frank W. Albert

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Interindividual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging. Here, we studied an F2 intercross of two outbred lines of rats selected for tame and aggressive behavior toward humans for .64 generations. By using a mapping approach that is able to identify genetic loci segregating within the lines, we identified four times more loci influencing tameness and aggression than by an approach that assumes fixation of causative alleles, suggesting that many causative loci were not driven to fixation by the selection. We used RNA sequencing in 150 F2 animals to identify hundreds of loci that influence brain gene expression. Several of these loci colocalize with tameness loci and may reflect the same genetic variants. Through analyses of correlations between allele effects on behavior and gene expression, differential expression between the tame and aggressive rat selection lines, and correlations between gene expression and tameness in F2 animals, we identify the genes Gltscr2, Lgi4, Zfp40, and Slc17a7 as candidate contributors to the strikingly different behavior of the tame and aggressive animals.

Original languageEnglish (US)
Pages (from-to)1277-1290
Number of pages14
JournalGenetics
Volume198
Issue number3
DOIs
StatePublished - Nov 1 2014

Bibliographical note

Publisher Copyright:
© 2014 by the Genetics Society of America.

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