Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

Gerard D. Schellenberg; Thomas D. Bird; Ellen M. Wijsman; Harry T. Orr; Leojean Anderson; Ellen Nemens; June A. White; Lori Bonnycastle; James L. Weber; M. Elisa Alonso; Huntington Potter; Leonard L. Heston; George M. Martin

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

Gerard D. Schellenberg, Thomas D. Bird, Ellen M. Wijsman, Harry T. Orr, Leojean Anderson, Ellen Nemens, June A. White, Lori Bonnycastle, James L. Weber, M. Elisa Alonso, Huntington Potter, Leonard L. Heston, George M. Martin

Laboratory Medicine and Pathology

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Abstract

Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Z_max of 9.15 (θ = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (θ = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Z_max = 5.94, θ = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.

Original language	English (US)
Pages (from-to)	668-671
Number of pages	4
Journal	Science
Volume	258
Issue number	5082
State	Published - Oct 23 1992

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title = "Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14",

abstract = "Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Zmax of 9.15 (θ = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (θ = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Zmax = 5.94, θ = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.",

author = "Schellenberg, {Gerard D.} and Bird, {Thomas D.} and Wijsman, {Ellen M.} and Orr, {Harry T.} and Leojean Anderson and Ellen Nemens and White, {June A.} and Lori Bonnycastle and Weber, {James L.} and Alonso, {M. Elisa} and Huntington Potter and Heston, {Leonard L.} and Martin, {George M.}",

year = "1992",

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language = "English (US)",

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pages = "668--671",

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T1 - Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

AU - Schellenberg, Gerard D.

AU - Bird, Thomas D.

AU - Wijsman, Ellen M.

AU - Orr, Harry T.

AU - Anderson, Leojean

AU - Nemens, Ellen

AU - White, June A.

AU - Bonnycastle, Lori

AU - Weber, James L.

AU - Alonso, M. Elisa

AU - Potter, Huntington

AU - Heston, Leonard L.

AU - Martin, George M.

PY - 1992/10/23

Y1 - 1992/10/23

N2 - Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Zmax of 9.15 (θ = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (θ = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Zmax = 5.94, θ = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.

AB - Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Zmax of 9.15 (θ = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (θ = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Zmax = 5.94, θ = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.

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JF - Science

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Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

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