Genetic topography of brain morphology

Chi Hua Chen, Mark Fiecas, E. D. Gutiérrez, Matthew S. Panizzon, Lisa T. Eyler, Eero Vuoksimaa, Wesley K. Thompson, Christine Fennema-Notestine, Donald J. Hagler, Terry L. Jernigan, Michael C. Neale, Carol E. Franz, Michael J. Lyons, Bruce Fischl, Ming T. Tsuang, Anders M. Dale, William S. Kremen

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Animal data show that cortical development is initially patterned by genetic gradients largely along three orthogonal axes. We previously reported differences in genetic influences on cortical surface area along an anterior-posterior axis using neuroimaging data of adult human twins. Here, we demonstrate differences in genetic influences on cortical thickness along a dorsal-ventral axis in the same cohort. The phenomenon of orthogonal gradations in cortical organization evident in different structural and functional properties may originate from genetic gradients. Another emerging theme of cortical patterning is that patterns of genetic influences recapitulate the spatial topography of the cortex within hemispheres. The genetic patterning of both cortical thickness and surface area corresponds to cortical functional specializations. Intriguingly, in contrast to broad similarities in genetic patterning, two sets of analyses distinguish cortical thickness and surface area genetically. First, genetic contributions to cortical thickness and surface area are largely distinct; there is very little genetic correlation (i.e., shared genetic influences) between them. Second, organizing principles among genetically defined regions differ between thickness and surface area. Examining the structure of the genetic similarity matrix among clusters revealed that, whereas surface area clusters showed great genetic proximity with clusters from the same lobe, thickness clusters appear to have close genetic relatedness with clusters that have similar maturational timing. The discrepancies are in line with evidence that the two traits follow different mechanisms in neurodevelopment. Our findings highlight the complexity of genetic influences on cortical morphology and provide a glimpse into emerging principles of genetic organization of the cortex.

Original languageEnglish (US)
Pages (from-to)17089-17094
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number42
DOIs
StatePublished - Oct 15 2013

Keywords

  • Genetics
  • Mri
  • Regionalization

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