Genome Editing of Plants

D. D. Songstad, J. F. Petolino, D. F. Voytas, N. A. Reichert

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Genome editing in organisms via random mutagenesis is a naturally occurring phenomenon. As a technology, genome editing has evolved from the use of chemical and physical mutagenic agents capable of altering DNA sequences to biological tools such as designed sequence-specific nucleases (SSN) to produce knock-out (KO) or knock-in (KI) edits and Oligonucleotide Directed Mutagenesis (ODM) where specific nucleotide changes are made in a directed manner resulting in custom single nucleotide polymorphisms (SNPs). Cibus' SU Canola™, which the US Department of Agriculture (USDA) views as non-genetically modified (non-GM), is Cibus' first commercial product arising from plant genome editing and had its test launch in 2014. Regulatory aspects of the various genome editing tools will be discussed.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalCritical Reviews in Plant Sciences
Volume36
Issue number1
DOIs
StatePublished - Jan 2 2017

Keywords

  • Biological mutagenesis
  • CRISPR
  • ODM
  • RTDS
  • SNP
  • TALENs
  • ZFN
  • chemical mutagenesis
  • knock-in
  • knock-out
  • single nucleotide polymorphism

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