Genome screening for linkage disequilibrium in a costa rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18

Michael A. Escamilla; L. Alison McInnes; Susan K. Service; Mitzi Spesny; Victor I. Reus; Julio Molina; Alvaro Gallegos; Eduardo Fournier; Steven Batki; Thomas Neylan; Carol Matthews; Sophia Vinogradov; Erin Roche; David J. Tyler; Norito Shimayoshi; Roxana Mendez; Rolando Ramirez; Margarita Ramirez; Carmen Araya; Xinia Araya; Pedro E. Leon; Lodewijk A. Sandkuijl; Nelson B. Freimer

doi:10.1002/ajmg.1205

Genome screening for linkage disequilibrium in a costa rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18

Michael A. Escamilla, L. Alison McInnes, Susan K. Service, Mitzi Spesny, Victor I. Reus, Julio Molina, Alvaro Gallegos, Eduardo Fournier, Steven Batki, Thomas Neylan, Carol Matthews, Sophia Vinogradov, Erin Roche, David J. Tyler, Norito Shimayoshi, Roxana Mendez, Rolando Ramirez, Margarita Ramirez, Carmen Araya, Xinia ArayaPedro E. Leon, Lodewijk A. Sandkuijl, Nelson B. Freimer

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Abstract

Linkage disequilibrium (LD) methods offer great promise for mapping complex traits, but have thus far been applied sparingly. In this paper we describe an LD mapping study of severe bipolar disorder (BP-I) in the genetically isolated population of the Central Valley of Costa Rica. This study provides the first complete screen of a chromosome for a complex trait using LD mapping and presents the first application of a new LD mapping statistic (ancestral haplotype reconstruction (AHR)) that evaluates haplotype sharing among affected individuals. The results of this chromosome-wide analysis are instructive for genome-wide LD mapping in isolated populations. Furthermore, the analysis continues to support a possible BP-I locus on 18pter, suggested by previous analyses in this population. Evidence for a possible BP-I locus on 18q12.2 is also described.

Original language	English (US)
Pages (from-to)	207-213
Number of pages	7
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	105
Issue number	2
DOIs	https://doi.org/10.1002/ajmg.1205
State	Published - Mar 8 2001
Externally published	Yes

Keywords

Association mapping
Complex phenotype
Population isolate

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Escamilla, M. A., McInnes, L. A., Service, S. K., Spesny, M., Reus, V. I., Molina, J., Gallegos, A., Fournier, E., Batki, S., Neylan, T., Matthews, C., Vinogradov, S., Roche, E., Tyler, D. J., Shimayoshi, N., Mendez, R., Ramirez, R., Ramirez, M., Araya, C., ... Freimer, N. B. (2001). Genome screening for linkage disequilibrium in a costa rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(2), 207-213. https://doi.org/10.1002/ajmg.1205

Genome screening for linkage disequilibrium in a costa rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18. / Escamilla, Michael A.; McInnes, L. Alison; Service, Susan K. et al.
In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 105, No. 2, 08.03.2001, p. 207-213.

Research output: Contribution to journal › Article › peer-review

Escamilla, MA, McInnes, LA, Service, SK, Spesny, M, Reus, VI, Molina, J, Gallegos, A, Fournier, E, Batki, S, Neylan, T, Matthews, C, Vinogradov, S, Roche, E, Tyler, DJ, Shimayoshi, N, Mendez, R, Ramirez, R, Ramirez, M, Araya, C, Araya, X, Leon, PE, Sandkuijl, LA & Freimer, NB 2001, 'Genome screening for linkage disequilibrium in a costa rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 105, no. 2, pp. 207-213. https://doi.org/10.1002/ajmg.1205

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abstract = "Linkage disequilibrium (LD) methods offer great promise for mapping complex traits, but have thus far been applied sparingly. In this paper we describe an LD mapping study of severe bipolar disorder (BP-I) in the genetically isolated population of the Central Valley of Costa Rica. This study provides the first complete screen of a chromosome for a complex trait using LD mapping and presents the first application of a new LD mapping statistic (ancestral haplotype reconstruction (AHR)) that evaluates haplotype sharing among affected individuals. The results of this chromosome-wide analysis are instructive for genome-wide LD mapping in isolated populations. Furthermore, the analysis continues to support a possible BP-I locus on 18pter, suggested by previous analyses in this population. Evidence for a possible BP-I locus on 18q12.2 is also described.",

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AU - Shimayoshi, Norito

AU - Mendez, Roxana

AU - Ramirez, Rolando

AU - Ramirez, Margarita

AU - Araya, Carmen

AU - Araya, Xinia

AU - Leon, Pedro E.

AU - Sandkuijl, Lodewijk A.

AU - Freimer, Nelson B.

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Genome screening for linkage disequilibrium in a costa rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18

Abstract

Keywords

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