Genome screening for linkage disequilibrium in a costa rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18

Michael A. Escamilla, L. Alison McInnes, Susan K. Service, Mitzi Spesny, Victor I. Reus, Julio Molina, Alvaro Gallegos, Eduardo Fournier, Steven Batki, Thomas Neylan, Carol Matthews, Sophia Vinogradov, Erin Roche, David J. Tyler, Norito Shimayoshi, Roxana Mendez, Rolando Ramirez, Margarita Ramirez, Carmen Araya, Xinia ArayaPedro E. Leon, Lodewijk A. Sandkuijl, Nelson B. Freimer

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Linkage disequilibrium (LD) methods offer great promise for mapping complex traits, but have thus far been applied sparingly. In this paper we describe an LD mapping study of severe bipolar disorder (BP-I) in the genetically isolated population of the Central Valley of Costa Rica. This study provides the first complete screen of a chromosome for a complex trait using LD mapping and presents the first application of a new LD mapping statistic (ancestral haplotype reconstruction (AHR)) that evaluates haplotype sharing among affected individuals. The results of this chromosome-wide analysis are instructive for genome-wide LD mapping in isolated populations. Furthermore, the analysis continues to support a possible BP-I locus on 18pter, suggested by previous analyses in this population. Evidence for a possible BP-I locus on 18q12.2 is also described.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number2
DOIs
StatePublished - Mar 8 2001
Externally publishedYes

Keywords

  • Association mapping
  • Complex phenotype
  • Population isolate

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