Genome-wide scans of genetic variants for psychophysiological endophenotypes: Introduction to this special issue of Psychophysiology

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

This special issue addresses the heritability and molecular genetic basis of 17 putative endophenotypes involving resting EEG power, P300 event-related potential amplitude, electrodermal orienting and habituation, antisaccade eye tracking, and affective modulation of the startle eye blink. These measures were collected from approximately 4,900 twins and parents who provided DNA samples through their participation in the Minnesota Twin Family Study. Included are papers that detail the methodology followed, genome-wide association analyses of single nucleotide polymorphisms and genes, analysis of rare variants in the human exome, and a whole genome sequencing study. Also included are 11 articles by leading experts in psychophysiology and genetics that provide perspective and commentary. A final integrative report summarizes findings and addresses issues raised. This introduction provides an overview of the aims and rationale behind these studies.

Original languageEnglish (US)
Pages (from-to)1201-1202
Number of pages2
JournalPsychophysiology
Volume51
Issue number12
DOIs
StatePublished - Dec 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Society for Psychophysiological Research.

Keywords

  • Endophenotypes
  • Minnesota Twin Family Study
  • Molecular genetics

Fingerprint Dive into the research topics of 'Genome-wide scans of genetic variants for psychophysiological endophenotypes: Introduction to this special issue of Psychophysiology'. Together they form a unique fingerprint.

Cite this