Glia instruct developmental neuronal remodeling through TGF-Î 2 signaling

Takeshi Awasaki, Yaling Huang, Michael B. O'Connor, Tzumin Lee

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

We found that glia secrete myoglianin, a TGF-β2 ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalNature neuroscience
Volume14
Issue number7
DOIs
StatePublished - Jul 2011

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