Global regulation of gene expression by ArlRS, a two-component signal transduction regulatory system of Staphylococcus aureus

Xudong Liang, Li Zheng, Christina Landwehr, Dwayne Lunsford, David Holmes, Yinduo Ji

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.

Original languageEnglish (US)
Pages (from-to)5486-5492
Number of pages7
JournalJournal of bacteriology
Volume187
Issue number15
DOIs
StatePublished - Aug 2005

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