TY - JOUR
T1 - Global regulation of gene expression by ArlRS, a two-component signal transduction regulatory system of Staphylococcus aureus
AU - Liang, Xudong
AU - Zheng, Li
AU - Landwehr, Christina
AU - Lunsford, Dwayne
AU - Holmes, David
AU - Ji, Yinduo
PY - 2005/8
Y1 - 2005/8
N2 - Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.
AB - Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=22544461904&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22544461904&partnerID=8YFLogxK
U2 - 10.1128/JB.187.15.5486-5492.2005
DO - 10.1128/JB.187.15.5486-5492.2005
M3 - Article
C2 - 16030243
AN - SCOPUS:22544461904
SN - 0021-9193
VL - 187
SP - 5486
EP - 5492
JO - Journal of bacteriology
JF - Journal of bacteriology
IS - 15
ER -