Glomerular basement membrane disorders in experimental models for renal diseases: Impact on understanding pathogenesis and improving diagnosis

Clifford E. Kashtan, Yoav Segal

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Animal models have provided important insights into human renal diseases that arise from mutations in genes that encode or regulate the synthesis of glomerular basement membrane proteins. This chapter describes several well-characterized animal models of type IV collagen disorders (Alport syndrome, HANAC syndrome), a laminin disorder (Pierson syndrome), nail-patella syndrome and HERNS syndrome. These models can be exploited in studies of the pathogenesis and treatment of such disorders.

Original languageEnglish (US)
Title of host publicationExperimental Models for Renal Diseases
Subtitle of host publicationPathogenesis and Diagnosis
EditorsGuillermo Herrera
Pages175-182
Number of pages8
DOIs
StatePublished - Jan 1 2011

Publication series

NameContributions to Nephrology
Volume169
ISSN (Print)0302-5144

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