Animal models have provided important insights into human renal diseases that arise from mutations in genes that encode or regulate the synthesis of glomerular basement membrane proteins. This chapter describes several well-characterized animal models of type IV collagen disorders (Alport syndrome, HANAC syndrome), a laminin disorder (Pierson syndrome), nail-patella syndrome and HERNS syndrome. These models can be exploited in studies of the pathogenesis and treatment of such disorders.
|Original language||English (US)|
|Title of host publication||Experimental Models for Renal Diseases|
|Subtitle of host publication||Pathogenesis and Diagnosis|
|Number of pages||8|
|State||Published - Jan 1 2011|
|Name||Contributions to Nephrology|