Glomerular disease and lung transplantation

Mark S Paller, Barbara Cahill, Keith R. Harmon, Robert B. Miller, Alan R Sinaiko, Barbara Burke, J. Carlos Manivel

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3 Scopus citations

Abstract

Three patients with lung or heart/lung transplants developed nephrotic-range proteinuria 2 to 5 years posttransplantation. Kidney biopsy showed focal segmental glomerulosclerosis in two patients and probable focal sclerosis in the third. A retrospective review of postmortem kidney specimens from 18 lung transplant recipients who died did not indicate additional cases of glomerular disease. The three patients with glomerular disease after lung transplantation had very few clinical similarities other than nephrotic-range proteinuria and lung transplantation. Their underlying lung diseases were different, and their posttransplantation courses were very different in terms of pulmonary function, cyclosporine nephrotoxicity, and other complications. We did not find in the literature previous reports of de novo focal segmental glomerulosclerosis or other glomerular lesions after lung transplantation. We suspect that additional cases will be identified in the future.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume26
Issue number3
DOIs
StatePublished - Sep 1995

Keywords

  • Focal segmental glomerulosclerosis
  • glomerulomegaly
  • lung transplantation
  • proteinuria

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