Glomerular renin synthesis and storage in the remnant kidney in the rat

Mark E. Rosenberg, Ricardo Correa-Rotter, Tadashi Inagami, Stefan Kren, Thomas H. Hostetter

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The intrarenal renin-angiotensin system can exert local control of the nephron and its circulation. In the subtotally nephrectomized model of chronic renal disease in the rat, angiotensin appears to play a prominent role in glomerular function. Glomeruli in this model demonstrate greater staining for intraglomerular renin by immunofluorescence microscopy than do those in control rats. Glomeruli from remnant nephrons contain increased renin content. Also, glomeruli from remnant nephrons contain an increased proportion of the mRNA for renin. Adriamycin-induced nephrosis did not evoke the same degree of renin staining and did not lead to increased glomerular expression of the renin gene, findings that argue against permselective defects and glomerular trapping as the sole cause of the glomerular renin in the remnant kidney model. Thus, renin synthesis and accumulation occur in the remnant glomerulus and this migration may underlie in part the dependence of glomerular function on the renin-angiotensin system in this model.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalKidney international
Volume40
Issue number4
DOIs
StatePublished - Oct 1991
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments This work was supported by National Institute of Health Grants

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