Glomerular structure in the normal human kidney: Differences between living and cadaver donors

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Abstract

Glomerular structure has been studied in tissues derived from normal living and cadaver kidney donors. Values obtained in such subjects were considered interchangeable and have been used to define the normal parameters when evaluating the effects of various renal diseases. The present study evaluated glomerular structure by light and electron microscopy in 83 living and 53 cadaver kidney donors. Glomerular basement membrane (GBM) width (356 ± 52 versus 329 ± 45 nm), glomerular volume (1.64 ± 0.47 versus 1.33 ± 0.39 × 106 μm3), and mesangial matrix volume per glomerulus (0.15 ± 0.05 versus 0.12 ± 0.04 × 106 μm3) were significantly greater in cadaver compared with living kidney donors, respectively. It is hypothesized that glomerular and extracellular matrix swelling is associated with the cadaver kidney preservation process. This study suggests that the normal values for glomerular structure should be derived only from living kidney donor tissues.

Original languageEnglish (US)
Pages (from-to)1901-1903
Number of pages3
JournalJournal of the American Society of Nephrology
Volume14
Issue number7
DOIs
StatePublished - Jul 1 2003

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