Abstract
A study of a series of S-alkylglutathiones as inhibitors of the enzyme, glyoxalase I, revealed that a non-polar region exists on the enzyme which plays an important role in the formation of an enzyme-inhibitor complex. The amount of inhibition of glyoxalase increases as the alkyl chain is lengthened from methyl to n-octyl. By taking advantage of the non-polar region of the enzyme, compounds have been prepared which are 435 times more active than the previously reported S-methylglutathione.
Original language | English (US) |
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Pages (from-to) | 593-598 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 35 |
Issue number | 5 |
DOIs | |
State | Published - Jun 6 1969 |
Bibliographical note
Funding Information:*Supported by Grant CA-10979-01 from the National Cancer Institute from the Minnesota Division of the American Cancer Society.