Gonadotropin receptors: Role of post-translational modifications and post-transcriptional regulation

K. M.J. Menon, Christine L. Clouser, Anil K. Nair

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

This review focuses on the post-translational modifications of LH and FSH receptors and recent studies on the regulation of LH receptor expression mediated by an RNA binding protein. Both LH and FSH receptors undergo extensive post-translational modifications. N-linked glycosylation occurs co-translationally and plays a role in the maturation and processing of the receptor, while palmitoylation is involved in receptor endocytosis and post-endocytic trafficking. A third type of post-translational modification is phosphorylation and its function has been reviewed. Finally, the regulation of LH receptor at the mRNA level by an RNA binding protein is discussed in the context of ovarian function.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalEndocrine
Volume26
Issue number3
DOIs
StatePublished - Apr 2005

Bibliographical note

Funding Information:
Supported by NIH Grant R37-HD-06656 CLC is a predoctoral fellow supported by NIH training grants 5 T32 HD 07048 and T3 GM 08353.

Keywords

  • Follicle stimulating hormone receptor
  • LHR mRNA binding protein
  • Luteinizing hormone receptor
  • Post-transcriptional regulation
  • Post-translational modifications

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