This review focuses on the post-translational modifications of LH and FSH receptors and recent studies on the regulation of LH receptor expression mediated by an RNA binding protein. Both LH and FSH receptors undergo extensive post-translational modifications. N-linked glycosylation occurs co-translationally and plays a role in the maturation and processing of the receptor, while palmitoylation is involved in receptor endocytosis and post-endocytic trafficking. A third type of post-translational modification is phosphorylation and its function has been reviewed. Finally, the regulation of LH receptor at the mRNA level by an RNA binding protein is discussed in the context of ovarian function.
Bibliographical noteFunding Information:
Supported by NIH Grant R37-HD-06656 CLC is a predoctoral fellow supported by NIH training grants 5 T32 HD 07048 and T3 GM 08353.
- Follicle stimulating hormone receptor
- LHR mRNA binding protein
- Luteinizing hormone receptor
- Post-transcriptional regulation
- Post-translational modifications