TY - JOUR
T1 - GRADE guidelines
T2 - 14. Going from evidence to recommendations: The significance and presentation of recommendations
AU - Andrews, Jeff
AU - Guyatt, Gordon
AU - Oxman, Andrew D.
AU - Alderson, Phil
AU - Dahm, Philipp
AU - Falck-Ytter, Yngve
AU - Nasser, Mona
AU - Meerpohl, Joerg
AU - Post, Piet N.
AU - Kunz, Regina
AU - Brozek, Jan
AU - Vist, Gunn
AU - Rind, David
AU - Akl, Elie A.
AU - Schünemann, Holger J.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/7
Y1 - 2013/7
N2 - This article describes the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to classifying the direction and strength of recommendations. The strength of a recommendation, separated into strong and weak, is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects. Alternative terms for a weak recommendation include conditional, discretionary, or qualified. The strength of a recommendation has specific implications for patients, the public, clinicians, and policy makers. Occasionally, guideline developers may choose to make "only-in-research" recommendations. Although panels may choose not to make recommendations, this choice leaves those looking for answers from guidelines without the guidance they are seeking. GRADE therefore encourages panels to, wherever possible, offer recommendations.
AB - This article describes the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to classifying the direction and strength of recommendations. The strength of a recommendation, separated into strong and weak, is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects. Alternative terms for a weak recommendation include conditional, discretionary, or qualified. The strength of a recommendation has specific implications for patients, the public, clinicians, and policy makers. Occasionally, guideline developers may choose to make "only-in-research" recommendations. Although panels may choose not to make recommendations, this choice leaves those looking for answers from guidelines without the guidance they are seeking. GRADE therefore encourages panels to, wherever possible, offer recommendations.
KW - GRADE
KW - Grading
KW - Guideline development
KW - Quality of evidence
KW - Recommendations
KW - Strength of evidence
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U2 - 10.1016/j.jclinepi.2012.03.013
DO - 10.1016/j.jclinepi.2012.03.013
M3 - Article
C2 - 23312392
AN - SCOPUS:84878246578
SN - 0895-4356
VL - 66
SP - 719
EP - 725
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 7
ER -