TY - JOUR
T1 - Graft loss due to recurrent disease in pediatric kidney transplant recipients on a rapid prednisone discontinuation protocol
AU - Chavers, Blanche M.
AU - Rheault, Michelle N.
AU - Gillingham, Kristen J.
AU - Matas, Arthur J.
PY - 2012/11
Y1 - 2012/11
N2 - Recurrent disease is the fourth most common cause of graft loss (GL) in pediatric KTx recipients. We studied the incidence of recurrent disease and GL due to recurrent disease in pediatric KTx recipients on a RDP protocol. Between 2002 and 2010, we performed 74 KTxs in patients aged 5-18 yr using an RDP protocol, 25 (34%) were at risk of recurrence of primary disease. Outcomes were compared to 69 historical controls (18 [26%] at risk of recurrence), KTx between 1996 and 2000. Follow-up period was 39 ± 25 months in RDP and 124 ± 38 months in controls. The incidence of recurrent disease at three yr post-KTx was 16% in RDP and 28% in controls (p = NS). Mean time to recurrent disease was 22 ± 26 months in RDP and 46 ± 48 months in controls (p = 0.54). Nine (12%) grafts were lost in the RDP group (1-recurrence) and 32 (46%) in the control group (4-recurrence). Time to GL was 85 months in the RDP recipient and 46 ± 21 months in controls. An RDP protocol in pediatric KTx recipients may not be associated with increased risk of graft loss due to recurrent disease.
AB - Recurrent disease is the fourth most common cause of graft loss (GL) in pediatric KTx recipients. We studied the incidence of recurrent disease and GL due to recurrent disease in pediatric KTx recipients on a RDP protocol. Between 2002 and 2010, we performed 74 KTxs in patients aged 5-18 yr using an RDP protocol, 25 (34%) were at risk of recurrence of primary disease. Outcomes were compared to 69 historical controls (18 [26%] at risk of recurrence), KTx between 1996 and 2000. Follow-up period was 39 ± 25 months in RDP and 124 ± 38 months in controls. The incidence of recurrent disease at three yr post-KTx was 16% in RDP and 28% in controls (p = NS). Mean time to recurrent disease was 22 ± 26 months in RDP and 46 ± 48 months in controls (p = 0.54). Nine (12%) grafts were lost in the RDP group (1-recurrence) and 32 (46%) in the control group (4-recurrence). Time to GL was 85 months in the RDP recipient and 46 ± 21 months in controls. An RDP protocol in pediatric KTx recipients may not be associated with increased risk of graft loss due to recurrent disease.
KW - disease recurrence
KW - graft loss
KW - pediatric kidney transplantation
KW - rapid discontinuation of prednisone
UR - http://www.scopus.com/inward/record.url?scp=84866741764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866741764&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3046.2012.01714.x
DO - 10.1111/j.1399-3046.2012.01714.x
M3 - Article
C2 - 22574837
AN - SCOPUS:84866741764
SN - 1397-3142
VL - 16
SP - 704
EP - 710
JO - Pediatric transplantation
JF - Pediatric transplantation
IS - 7
ER -