It has been unclear whether a graft-versus-leukemia (GVL) effect assists in the control of juvenile myelomonocytic leukemia (JMML) following allogeneic bone marrow transplant. We describe a patient with JMML who relapsed early after an unrelated donor transplant, and following withdrawal of immunosuppression developed graft-versus-host disease (GVHD). Associated with GVHD the proportion of donor cells measured by variable nucleotide tandem repeat (VNTR) analysis increased, and peripheral blasts and cutaneous disease were eliminated. These findings strongly suggest that GVL has a role in the control of JMML.
Bibliographical noteFunding Information:
We thank Dr Terry Wood for his confidence in referral of this patient to the University of Minnesota. This work was supported by P01-CA21737, the Children’s Cancer Research Fund, the Bone Marrow Transplant Research Fund, the American Cancer Society and the Minnesota Medical Foundation. PJO is a recipient of an American Cancer Society Career Development Award.
- Donor lymphocytes