Graft-versus-leukemia is sufficient to induce remission in juvenile myelomonocytic leukemia

P. J. Orchard; J. S. Miller; R. McGlennen; S. M. Davies; N. K.C. Ramsay

doi:10.1038/sj.bmt.1701305

Graft-versus-leukemia is sufficient to induce remission in juvenile myelomonocytic leukemia

P. J. Orchard, J. S. Miller, R. McGlennen, S. M. Davies, N. K.C. Ramsay

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

It has been unclear whether a graft-versus-leukemia (GVL) effect assists in the control of juvenile myelomonocytic leukemia (JMML) following allogeneic bone marrow transplant. We describe a patient with JMML who relapsed early after an unrelated donor transplant, and following withdrawal of immunosuppression developed graft-versus-host disease (GVHD). Associated with GVHD the proportion of donor cells measured by variable nucleotide tandem repeat (VNTR) analysis increased, and peripheral blasts and cutaneous disease were eliminated. These findings strongly suggest that GVL has a role in the control of JMML.

Original language	English (US)
Pages (from-to)	201-203
Number of pages	3
Journal	Bone marrow transplantation
Volume	22
Issue number	2
DOIs	https://doi.org/10.1038/sj.bmt.1701305
State	Published - 1998

Bibliographical note

Funding Information:
We thank Dr Terry Wood for his confidence in referral of this patient to the University of Minnesota. This work was supported by P01-CA21737, the Children’s Cancer Research Fund, the Bone Marrow Transplant Research Fund, the American Cancer Society and the Minnesota Medical Foundation. PJO is a recipient of an American Cancer Society Career Development Award.

Keywords

Donor lymphocytes
GVHD
GVL
JCML
JMML

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title = "Graft-versus-leukemia is sufficient to induce remission in juvenile myelomonocytic leukemia",

abstract = "It has been unclear whether a graft-versus-leukemia (GVL) effect assists in the control of juvenile myelomonocytic leukemia (JMML) following allogeneic bone marrow transplant. We describe a patient with JMML who relapsed early after an unrelated donor transplant, and following withdrawal of immunosuppression developed graft-versus-host disease (GVHD). Associated with GVHD the proportion of donor cells measured by variable nucleotide tandem repeat (VNTR) analysis increased, and peripheral blasts and cutaneous disease were eliminated. These findings strongly suggest that GVL has a role in the control of JMML.",

keywords = "Donor lymphocytes, GVHD, GVL, JCML, JMML",

author = "Orchard, {P. J.} and Miller, {J. S.} and R. McGlennen and Davies, {S. M.} and Ramsay, {N. K.C.}",

note = "Funding Information: We thank Dr Terry Wood for his confidence in referral of this patient to the University of Minnesota. This work was supported by P01-CA21737, the Children{\textquoteright}s Cancer Research Fund, the Bone Marrow Transplant Research Fund, the American Cancer Society and the Minnesota Medical Foundation. PJO is a recipient of an American Cancer Society Career Development Award.",

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AU - Davies, S. M.

AU - Ramsay, N. K.C.

N1 - Funding Information: We thank Dr Terry Wood for his confidence in referral of this patient to the University of Minnesota. This work was supported by P01-CA21737, the Children’s Cancer Research Fund, the Bone Marrow Transplant Research Fund, the American Cancer Society and the Minnesota Medical Foundation. PJO is a recipient of an American Cancer Society Career Development Award.

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AB - It has been unclear whether a graft-versus-leukemia (GVL) effect assists in the control of juvenile myelomonocytic leukemia (JMML) following allogeneic bone marrow transplant. We describe a patient with JMML who relapsed early after an unrelated donor transplant, and following withdrawal of immunosuppression developed graft-versus-host disease (GVHD). Associated with GVHD the proportion of donor cells measured by variable nucleotide tandem repeat (VNTR) analysis increased, and peripheral blasts and cutaneous disease were eliminated. These findings strongly suggest that GVL has a role in the control of JMML.

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