Granulocyte antigen systems and antibodies and their clinical significance

Jeffrey McCullough

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced neutropenia, and neutropenias secondary to many other diseases. Although many techniques are available for detecting granulocyte antibodies, the optimal in-vitro tests for predicting the antibodies' clinical effects are not established. Use of indium-111-labeled granulocytes may provide valuable information regarding the in-vivo effects of different granulocyte antibodies. Granulocyte transfusions continue to be used for a limited number of severely infected neutropenic patients who do not respond to antibiotic therapy.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalHuman pathology
Issue number3
StatePublished - Mar 1983

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