Graphene quantum dots enhance anticancer activity of cisplatin via increasing its cellular and nuclear uptake

Xin Sui; Chao Luo; Chong Wang; Fangwei Zhang; Jingyan Zhang; Shouwu Guo

doi:10.1016/j.nano.2016.03.010

Graphene quantum dots enhance anticancer activity of cisplatin via increasing its cellular and nuclear uptake

Xin Sui, Chao Luo, Chong Wang, Fangwei Zhang, Jingyan Zhang, Shouwu Guo

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Using assistant reagents to improve the pharmaceutical performance of cisplatin (CDDP) has been one of promising strategies. Owing to their extraordinary properties, graphene quantum dots (GQDs) have shown great potentials in biomedical applications. Here we demonstrate that the combination of GQDs with CDDP can effectively enhance the cytotoxicity, cell cycle arrest, and DNA fragmentation that induced by CDDP. We also found that the GQDs improved the interaction of CDDP with DNA. Combing these results with our previous finding that graphene oxide could enhance the permeability of the cells, we believe GQDs improve the pharmaceutical performance of CDDP via first increasing its cellular uptake through improving the cell permeability, and then reinforcing its interaction with DNA once it is inside cells. The remarkable enhancement to CDDP cellular uptake in CDDP resistant cells further specifies that GQDs can increase chemotherapy efficacy of anticancer drugs that are suboptimal due to the drug resistance.

Original language	English (US)
Pages (from-to)	1997-2006
Number of pages	10
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/j.nano.2016.03.010
State	Published - Oct 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
This research was carried out with financial support from the national “973 Program” of China (Nos. 2015CB931801, 2014CB260411), National Science foundation of China (No. 11374205), the state key laboratory of bioreactor engineering (No. 2060204), 111 Project (No. B07023), the Shanghai Committee of Science and Technology (Nos. 11DZ2260600), and national “863” Program of China (No. 2012AA022603) for financial support of this work..

Publisher Copyright:
© 2016 Elsevier Inc.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Anticancer activity
Cell permeability
Cellular uptake
Cisplatin
Graphene quantum dots

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Graphene quantum dots enhance anticancer activity of cisplatin via increasing its cellular and nuclear uptake

Abstract

Bibliographical note

Keywords

UN SDGs

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