GRAS flavoring substances 25

R. L. Smith; W. J. Waddell; S. M. Cohen; S. Fukushima; N. J. Gooderham; S. S. Hecht; L. J. Marnett; P. S. Portoghese; I. M C M Rietjens; T. B. Adams; C. Lucas Gavin; M. M. Mcgowen; S. V. Taylor

GRAS flavoring substances 25

R. L. Smith, W. J. Waddell, S. M. Cohen, S. Fukushima, N. J. Gooderham, S. S. Hecht, L. J. Marnett, P. S. Portoghese, I. M C M Rietjens, T. B. Adams, C. Lucas Gavin, M. M. Mcgowen, S. V. Taylor

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Abstract

Flavor and Extract Manufacturers Association (FEMA) provides an update on recent progress in the consideration of flavoring ingredients generally recognized as safe (GRAS) under the Food Additives Amendment. The Panel re-evaluated all relevant metabolic and toxicity data for these flavor ingredients within the context of their increased use levels in chewing gum. Pyridine was reaffirmed as GRAS (GRASr) in 2010 based upon its efficient detoxification in humans; its low level of flavor use; the lack of genotoxic and mutagenic potential. The substance 2-hexyl- 4-acetoxytetrahydrofuran was removed from the GRAS list. The FEMA Expert Panel concludes that the neutral, hydrated, and salt forms of GRAS substances that are physiologically equivalent are assigned the same GRAS number. The same GRAS number would also be applied to the sodium, potassium, calcium, ferrous, ferric, ammonium, and quaternary ammonium salts derived from FEMA GRAS amines, carboxylates, sulfonates, sulfamates, or sulfates.

Original language	English (US)
Pages (from-to)	44-75
Number of pages	32
Journal	Food Technology
Volume	65
Issue number	7
State	Published - Jul 2011

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abstract = "Flavor and Extract Manufacturers Association (FEMA) provides an update on recent progress in the consideration of flavoring ingredients generally recognized as safe (GRAS) under the Food Additives Amendment. The Panel re-evaluated all relevant metabolic and toxicity data for these flavor ingredients within the context of their increased use levels in chewing gum. Pyridine was reaffirmed as GRAS (GRASr) in 2010 based upon its efficient detoxification in humans; its low level of flavor use; the lack of genotoxic and mutagenic potential. The substance 2-hexyl- 4-acetoxytetrahydrofuran was removed from the GRAS list. The FEMA Expert Panel concludes that the neutral, hydrated, and salt forms of GRAS substances that are physiologically equivalent are assigned the same GRAS number. The same GRAS number would also be applied to the sodium, potassium, calcium, ferrous, ferric, ammonium, and quaternary ammonium salts derived from FEMA GRAS amines, carboxylates, sulfonates, sulfamates, or sulfates.",

author = "Smith, {R. L.} and Waddell, {W. J.} and Cohen, {S. M.} and S. Fukushima and Gooderham, {N. J.} and Hecht, {S. S.} and Marnett, {L. J.} and Portoghese, {P. S.} and Rietjens, {I. M C M} and Adams, {T. B.} and Gavin, {C. Lucas} and Mcgowen, {M. M.} and Taylor, {S. V.}",

year = "2011",

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language = "English (US)",

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AU - Smith, R. L.

AU - Waddell, W. J.

AU - Cohen, S. M.

AU - Fukushima, S.

AU - Gooderham, N. J.

AU - Hecht, S. S.

AU - Marnett, L. J.

AU - Portoghese, P. S.

AU - Rietjens, I. M C M

AU - Adams, T. B.

AU - Gavin, C. Lucas

AU - Mcgowen, M. M.

AU - Taylor, S. V.

PY - 2011/7

Y1 - 2011/7

N2 - Flavor and Extract Manufacturers Association (FEMA) provides an update on recent progress in the consideration of flavoring ingredients generally recognized as safe (GRAS) under the Food Additives Amendment. The Panel re-evaluated all relevant metabolic and toxicity data for these flavor ingredients within the context of their increased use levels in chewing gum. Pyridine was reaffirmed as GRAS (GRASr) in 2010 based upon its efficient detoxification in humans; its low level of flavor use; the lack of genotoxic and mutagenic potential. The substance 2-hexyl- 4-acetoxytetrahydrofuran was removed from the GRAS list. The FEMA Expert Panel concludes that the neutral, hydrated, and salt forms of GRAS substances that are physiologically equivalent are assigned the same GRAS number. The same GRAS number would also be applied to the sodium, potassium, calcium, ferrous, ferric, ammonium, and quaternary ammonium salts derived from FEMA GRAS amines, carboxylates, sulfonates, sulfamates, or sulfates.

AB - Flavor and Extract Manufacturers Association (FEMA) provides an update on recent progress in the consideration of flavoring ingredients generally recognized as safe (GRAS) under the Food Additives Amendment. The Panel re-evaluated all relevant metabolic and toxicity data for these flavor ingredients within the context of their increased use levels in chewing gum. Pyridine was reaffirmed as GRAS (GRASr) in 2010 based upon its efficient detoxification in humans; its low level of flavor use; the lack of genotoxic and mutagenic potential. The substance 2-hexyl- 4-acetoxytetrahydrofuran was removed from the GRAS list. The FEMA Expert Panel concludes that the neutral, hydrated, and salt forms of GRAS substances that are physiologically equivalent are assigned the same GRAS number. The same GRAS number would also be applied to the sodium, potassium, calcium, ferrous, ferric, ammonium, and quaternary ammonium salts derived from FEMA GRAS amines, carboxylates, sulfonates, sulfamates, or sulfates.

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GRAS flavoring substances 25

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