Greater adherence to life’s simple 7 is associated with less arterial stiffness: The Atherosclerosis risk in Communities (ARIC) study

Abayomi O. Oyenuga, Aaron R. Folsom, Susan Cheng, Hirofumi Tanaka, Michelle L. Meyer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

BACKGROUND Greater arterial stiffness is associated independently with increased cardiovascular disease risk. The American Heart Association (AHA) has recommended following “Life’s Simple 7 (LS7)” to optimize cardiovascular health; we tested whether better LS7 in middle age is associated with less arterial stiffness in later life. METHODS We studied 4,232 black and white participants aged 45–64 years at the baseline (1987–89) visit of the Atherosclerosis Risk in Communities Study cohort who also had arterial stiffness measured in 2011–13 (mean ± SD interval: 23.6 ± 1.0 years). We calculated a 14-point summary score for baseline LS7 and classified participants as having “poor” (0–4), “average” (5–9), or “ideal” (10–14) cardiovascular health. We used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (95% CI) for arterial stiffening: a high carotid-femoral pulse wave velocity (cfPWV, ≥13.23 m/s) or a high central pulse pressure (central PP, ≥ 82.35 mm Hg). RESULTS The age, race, sex, and heart rate-adjusted ORs (95% CI) for high cfPWV in the “ideal,” “average,” and “poor” LS7 summary categories were 1 (Reference), 1.30 (1.11, 1.53), and 1.68 (1.10,2.56), respectively (P-trend = 0.0003). Similarly, the adjusted ORs (95% CI) for high central PP across LS7 summary categories were 1 (Reference), 1.48 (1.27, 1.74), and 1.63 (1.04, 2.56), respectively (P-trend <0.0001). CONCLUSION Greater LS7 score in middle age is associated with less arterial stiffness 2–3 decades later. These findings further support the AHA recommendation to follow LS7 for cardiovascular disease prevention.

Original languageEnglish (US)
Pages (from-to)769-776
Number of pages8
JournalAmerican journal of hypertension
Volume32
Issue number8
DOIs
StatePublished - Jul 17 2019

Bibliographical note

Publisher Copyright:
© American Journal of Hypertension, Ltd 2019. All rights reserved.

Keywords

  • Arterial elasticity
  • Atherosclerosis Risk in Communities Study
  • Blood pressure
  • Central pulse pressure
  • Hypertension
  • Life’s Simple 7
  • Pulse wave velocity

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