Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131

James R Johnson, Stephen B. Porter, Paul Thuras, Tim Johnson, Lance B. Price, Veronika Tchesnokova, Evgeni V. Sokurenko

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Minimum bactericidal concentrations (MBCs) for ciprofloxacin were significantly higher among 41 members of the H30 subclone within Escherichia coli sequence type 131 than among 48 other fluoroquinolone-resistant E. coli isolates. This MBC difference, which was not explained by ciprofloxacin MICs, gyrA, parC, and parE mutations, the presence of aac(6=)-Ib-cr, or organic solvent tolerance (a surrogate for efflux pump activity), conceivably could have promoted the pandemic emergence of the H30 sequence type 131 subclone.

Original languageEnglish (US)
Pages (from-to)7132-7135
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume59
Issue number11
DOIs
StatePublished - Nov 1 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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