Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments

S. A. Krumins, D. C. Kim, O. J. Igwe, A. A. Larson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Studies, designed to delineate the portions of substance P (SP) molecule needed for reversal of GppNHP-induced inhibition of DAMGO binding, have shown that nanomolar concentrations of SP fragments containing the N-terminus of SP reduce both the K(d) and B(max) values of DAMGO binding to a high-affinity site.

Original languageEnglish (US)
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages163-165
Number of pages3
ISBN (Print)044481213X
StatePublished - Jan 1 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Publication series

NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

Fingerprint Dive into the research topics of 'Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments'. Together they form a unique fingerprint.

Cite this