TY - JOUR
T1 - Guidelines for Infection Prophylaxis, Monitoring and Therapy in Cord Blood Transplantation
AU - American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group
AU - Olson, Amanda L.
AU - Politikos, Ioannis
AU - Brunstein, Claudio
AU - Milano, Fillipo
AU - Barker, Juliet
AU - Hill, Joshua A.
N1 - Publisher Copyright:
© 2021 The American Society for Transplantation and Cellular Therapy
PY - 2021/5
Y1 - 2021/5
N2 - As an alternative stem cell source, cord blood (CB) has many advantages. However, delayed engraftment, lack of transferred immunity, and a significant incidence of acute graft-versus-host disease renders CB transplant (CBT) recipients at high risk of infectious complications. This guidance written by CBT and infectious disease experts outlines evidence-based recommendations for the prevention and treatment of opportunistic infections in adult patients undergoing CBT. Topics addressed include bacterial, fungal, viral, pneumocystis jirovcii and toxoplasmosis prophylaxis, suggested PCR monitoring for viruses, therapy for the most commonly encountered infections after CBT. We review key concepts including the recent important role of letermovir in the prevention of CMV reactivation. In instances where there is a paucity of data, practice recommendations are provided, including the duration of antimicrobial prophylaxis.
AB - As an alternative stem cell source, cord blood (CB) has many advantages. However, delayed engraftment, lack of transferred immunity, and a significant incidence of acute graft-versus-host disease renders CB transplant (CBT) recipients at high risk of infectious complications. This guidance written by CBT and infectious disease experts outlines evidence-based recommendations for the prevention and treatment of opportunistic infections in adult patients undergoing CBT. Topics addressed include bacterial, fungal, viral, pneumocystis jirovcii and toxoplasmosis prophylaxis, suggested PCR monitoring for viruses, therapy for the most commonly encountered infections after CBT. We review key concepts including the recent important role of letermovir in the prevention of CMV reactivation. In instances where there is a paucity of data, practice recommendations are provided, including the duration of antimicrobial prophylaxis.
KW - blood transplantation
KW - cbt
KW - cord
KW - infection prophylaxis
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U2 - 10.1016/j.jtct.2021.01.024
DO - 10.1016/j.jtct.2021.01.024
M3 - Article
C2 - 33965172
AN - SCOPUS:85105351172
SN - 2666-6367
VL - 27
SP - 359
EP - 362
JO - Transplantation and Cellular Therapy
JF - Transplantation and Cellular Therapy
IS - 5
ER -