H-2 antigen class: Effect on mouse islet allograft rejection

C. E. Morrow, D. E R Sutherland, M. W. Steffes, J. S. Najarian, F. H. Bach

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Rejection of mouse pancreatic islet allografts occurred in a high percentage of donor recipient combinations identical for H-2I-region antigens and differing at H-2K and H-2K + H-2D without I-region disparities. The results suggest that disparities in major histocompatibility complex antigens of class I (H-2K and H-2D) alone are capable of eliciting islet allograft rejection, and that lack of a stimulus from class II (I-region) alloantigens does not ensure permanent islet allograft survival.

Original languageEnglish (US)
Pages (from-to)1337-1339
Number of pages3
JournalScience
Volume219
Issue number4590
StatePublished - 1983

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

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