Patterns of allele-specific expression of H19 and insulin-like growth factor-2 (IGF-2) were examined in tissue obtained from 30 children diagnosed with hepatoblastoma. All informative tumours demonstrated monoallelic expression of H19. In contrast, variable patterns of allele-specific expression of IGF-2 were seen in tumours from children of different ages. (C) 2000 Cancer Research Campaign.
Bibliographical noteFunding Information:
Supported by a grant from the Children’s Cancer Research Fund and NIH Grant N01-DK-6-2274. Hepatoblastoma tissue and normal matched liver tissue was kindly provided by the Children’s Cancer Group and the Pediatric Oncology Group through the Pediatric Division of the Cooperative Human Tissue Network funded by the National Cancer Institute. The authors wish to thank Peter Schmidt and Catherine Moen for technical assistance.
- Genomic imprinting