H19 and IGF-2 allele-specific expression in hepatoblastoma

J. A. Ross, G. A. Radloff, S. M. Davies

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Patterns of allele-specific expression of H19 and insulin-like growth factor-2 (IGF-2) were examined in tissue obtained from 30 children diagnosed with hepatoblastoma. All informative tumours demonstrated monoallelic expression of H19. In contrast, variable patterns of allele-specific expression of IGF-2 were seen in tumours from children of different ages. (C) 2000 Cancer Research Campaign.

Original languageEnglish (US)
Pages (from-to)753-756
Number of pages4
JournalBritish Journal of Cancer
Volume82
Issue number4
DOIs
StatePublished - 2000

Bibliographical note

Funding Information:
Supported by a grant from the Children’s Cancer Research Fund and NIH Grant N01-DK-6-2274. Hepatoblastoma tissue and normal matched liver tissue was kindly provided by the Children’s Cancer Group and the Pediatric Oncology Group through the Pediatric Division of the Cooperative Human Tissue Network funded by the National Cancer Institute. The authors wish to thank Peter Schmidt and Catherine Moen for technical assistance.

Keywords

  • Genomic imprinting
  • H19
  • Hepatoblastoma
  • IGF-2

Fingerprint

Dive into the research topics of 'H19 and IGF-2 allele-specific expression in hepatoblastoma'. Together they form a unique fingerprint.

Cite this